Department

Exploratory Research Center on Life and Living Systems, Department of Creative Research
Concurrent Position:
Life and Coordination-Complex Molecular Science, Biomolecular Functions / Research Center of Integrative Molecular Systems, Division of Biomolecular Systems

Biography

1982 B.S. Tokyo Institute of Technology
1987 Ph.D. Tokyo Institute of Technology
1988 Postdoctoral Fellow, Georgia University
1989 Assistant Professor, Tokyo Institute of Technology
1994 Assistant Professor, Japan Advanced Institute of Science and Technology
2002 Professor, Okazaki Institute for Integrative Bioscience (-2018.3)
        Professor, Institute for Molecular Science
        Professor, The Graduate University for Advanced Studies
2018 Professor, Exploratory Research Center on Life and Living Systems

Main research themes

Bioinorganic Chemistry of Metalloproteins Responsible for Signal Transduction

Bioinorganic Chemistry, Metalloproteins, Sensor Protein

Annual Review : PDF

Selected Publications

1. "Heme controls the structural rearrangement of its sensor protein mediating bacterial survival", M. Nishinaga, H. Sugimoto, Y. Nishitani, S. Nagai, S. Nagatoishi, N. Muraki, T. Tosha, K. Tsumoto, S. Aono, Y. Shiro, and H. Sawai, Commun. Biol. 2021, 4, 467 (12 pages) (2021).
2. "Structural characterization of thermoglobin from a hyperthermophilic bacterium Aquifex aeolicus", N. Muraki, K. Takeda, D. Nam, M. Muraki, and S. Aono, Chem. Lett. 2021, 50, 603-606 (2021).
3. "Structural basis for heme transfer reaction in heme uptake machinery from Corynebacteria" N. Muraki, C. K., Y. Okamoto, T. Uchida, K. Ishimori, and S. Aono, Chem. Commun. 55, 13864-13867 (2019).
4. "Structural characterization of HypX responsible for CO biosynthesis in the maturation of NiFe-hydrogenase" N. Muraki, K. Ishii, S. Uchiyama, S. G. Itoh, H. Okumura, and S. Aono, Commun. Biol. 2, 385 (2019).
5. “Protein Dynamics of the Sensor Protein HemAT as Probed by Time-Resolved Step-Scan FTIR Spectroscopy,” A. Pavlou, H. Yoshimura, S. Aono, E. Pinakoulaki, Biophys. J. 114, 584-591 (2018).
6. “Probing the role of the heme distal and proximal environment in ligand dynamics in the signal transducer protein HemAT by time-resolved step-scan FTIR and resonance Raman spectroscopy,” A. Pavlou, A. Loullis, H. Yoshimura, S. Aono, E. Pinakoulaki, Biochemistry, 56, 5309-5317 (2017).